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課程名稱 |
基因體研究特論
Special Topics in Genomic Studies |
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開課學期 |
112-1 |
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授課對象 |
共同教育中心 統計碩士學位學程 |
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授課教師 |
郭柏秀 |
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課號 |
EPM7181 |
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課程識別碼 |
849 M0750 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三3,4(10:20~12:10) |
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上課地點 |
公衛210 |
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備註 |
生醫資訊與生物統計學領域選修課程之一。與盧子彬、馮嬿臻合授
限碩士班以上
總人數上限：15人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. We’ll cover topics related to a) Study design, data analysis and integration; b) Assessment of human genome variation and regulation; c) Using genomic information in medicine and public health. |
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課程目標 |
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies. |
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課程要求 |
[具備基礎遺傳學知識，或修習過遺傳流行病學原理、其他授課教師認可之遺傳相關課程]
Class participation (45%), assignments (25%), and final report (30%).
Class participation: including presentation and discussion.
Assignments: written discussion about the designated questions listed in each session.
Final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field. |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註： By email to make appointment. |
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指定閱讀 |
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參考書目 |
Human Genome Epidemiology, 2nd Edition
Building the evidence for using genetic information to improve health and
prevent disease.
Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Class participation |
45% |
Including presentation and discussion. |
2. |
Assignments |
25% |
Written discussion about the designated questions listed in each session. |
3. |
Final report |
30% |
Choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field. |
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週次 |
日期 |
單元主題 |
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第1週 |
9/6 |
Module I：GWAS in complex traits 郭柏秀 |
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第2週 |
9/13 |
Module I：Understanding polygenic risk score (PRS) 郭柏秀 |
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第3週 |
9/20 |
Module I：Pharmacogenomics in real world 郭柏秀 |
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第4週 |
9/27 |
Module I：Case study (presentation) |
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第5週 |
10/4 |
Module II：Introduction of rare variants 盧子彬 |
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第6週 |
10/11 |
Module II：The roles of non-coding variants 馮嬿臻 |
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第7週 |
10/18 |
Module II：Applications of rare variants studies 馮嬿臻 |
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第8週 |
10/25 |
Module II：Case study (presentation) |
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第9週 |
11/1 |
Module III：Introduction of metagenomics 郭柏秀 |
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第10週 |
11/8 |
Module III：Applications of metagenomics studies 盧子彬 |
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第11週 |
11/15 |
Module III：Case study (presentation) |
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第12週 |
11/22 |
Module IV：Introduction of biobank and TPMI 郭柏秀 |
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第13週 |
11/29 |
Module IV：Applications of biobank studies 馮嬿臻 |
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第14週 |
12/6 |
Module IV：Case study (presentation) |
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第15週 |
12/13 |
Final report |
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第16週 |
12/20 |
Final report |
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